[HTML][HTML] Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response
KT Chambers, TC Leone, N Sambandam… - Journal of Biological …, 2011 - ASBMB
Diabetic cardiac dysfunction is associated with decreased rates of myocardial glucose
oxidation (GO) and increased fatty acid oxidation (FAO), a fuel shift that has been shown to
sensitize the heart to ischemic insult and ventricular dysfunction. We sought to evaluate the
metabolic and functional consequences of chronic suppression of GO in heart as modeled
by transgenic mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase
4 (myosin heavy chain (MHC)-PDK4 mice), an inhibitor of pyruvate dehydrogenase. Hearts …
oxidation (GO) and increased fatty acid oxidation (FAO), a fuel shift that has been shown to
sensitize the heart to ischemic insult and ventricular dysfunction. We sought to evaluate the
metabolic and functional consequences of chronic suppression of GO in heart as modeled
by transgenic mice with cardiac-specific overexpression of pyruvate dehydrogenase kinase
4 (myosin heavy chain (MHC)-PDK4 mice), an inhibitor of pyruvate dehydrogenase. Hearts …