[HTML][HTML] Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis
J Durgan, N Kaji, D Jin, A Hall - Journal of Biological Chemistry, 2011 - ASBMB
Cdc42 plays an evolutionarily conserved role in promoting cell polarity and is indispensable
during epithelial morphogenesis. To further investigate the role of Cdc42, we have used a
three-dimensional matrigel model, in which single Caco-2 cells develop to form polarized
cysts. Using this system, we previously reported that Cdc42 controls mitotic spindle
orientation during cell division to correctly position the apical surface in a growing epithelial
structure. In the present study, we have investigated the specific downstream effectors …
during epithelial morphogenesis. To further investigate the role of Cdc42, we have used a
three-dimensional matrigel model, in which single Caco-2 cells develop to form polarized
cysts. Using this system, we previously reported that Cdc42 controls mitotic spindle
orientation during cell division to correctly position the apical surface in a growing epithelial
structure. In the present study, we have investigated the specific downstream effectors …