Cyclin D1 encodes a regulatory subunit, which with its cyclin-dependent kinase (Cdk)-
binding partner forms a holoenzyme that phosphorylates and inactivates the retinoblastoma
protein. In addition to its Cdk binding-dependent functions, cyclin D1 regulates cellular
differentiation in part by modifying several transcription factors and nuclear receptors. The
molecular mechanism through which cyclin D1 regulates the function of transcription factors
involved in cellular differentiation remains to be clarified. The histone acetyltransferase …