[PDF][PDF] Guanylyl cyclase receptors.

DL Garbers, D Koesling, G Schultz - Molecular biology of the cell, 1994 - Am Soc Cell Biol
For about two decades, the enzymes (guanylyl cyclases) that synthesize cyclic GMP have
been described as soluble or particulate, depending upon where they are found in a cell
homogenate (Kimura and Murad, 1974; Chrisman et al., 1975). The particulate forms have
been often further separated into those that are easilysolubilized with nonionic detergents
and those that are not. Early studies suggested that the enzymes found in the soluble and
particulate fractions were different proteins, and the cloning of the mRNA not only confirmed …