Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire
J Boffey, M Odaka, D Nicoll, ER Wagner… - Journal of …, 2005 - Elsevier
Neuropathogenic murine antibodies reactive with terminal disialylgalactose epitopes are
innate and preferentially encoded by the VH7183. 3b gene. Here we have studied
antibodies reactive with internal galactose-linked disialosyl epitopes and the terminal
trisaccharide of GT1b. Antibodies were of moderate affinity and unmutated. Anti-GD1b
antibodies were often encoded by the VH10. 2b heavy and gj38c light chain genes. Anti-
GT1b antibodies with broader glycan binding patterns were encoded by VHQ52 and …
innate and preferentially encoded by the VH7183. 3b gene. Here we have studied
antibodies reactive with internal galactose-linked disialosyl epitopes and the terminal
trisaccharide of GT1b. Antibodies were of moderate affinity and unmutated. Anti-GD1b
antibodies were often encoded by the VH10. 2b heavy and gj38c light chain genes. Anti-
GT1b antibodies with broader glycan binding patterns were encoded by VHQ52 and …