[HTML][HTML] Platelet-derived growth factor receptor β regulates migration and DNA synthesis in metanephric mesenchymal cells
M Arar, YC Xu, I Elshihabi, JL Barnes… - Journal of Biological …, 2000 - ASBMB
Platelet-derived growth factor (PDGF) B-chain and PDGF receptor β (PDGFR β) are
essential for glomerulogenesis. Mice deficient in PDGF B-chain or PDGFR β exhibit an
abnormal glomerular phenotype characterized by total lack of mesangial cells. In this study,
we localized PDGFR β in the developing rat kidney and explored the biological effects of
PDGF in metanephric mesenchymal cells in an attempt to determine the mechanism by
which PDGF regulates mesangial cell development. Immunohistochemical and in …
essential for glomerulogenesis. Mice deficient in PDGF B-chain or PDGFR β exhibit an
abnormal glomerular phenotype characterized by total lack of mesangial cells. In this study,
we localized PDGFR β in the developing rat kidney and explored the biological effects of
PDGF in metanephric mesenchymal cells in an attempt to determine the mechanism by
which PDGF regulates mesangial cell development. Immunohistochemical and in …