TIS21 negatively regulates hepatocarcinogenesis by disruption of cyclin B1–Forkhead box M1 regulation loop
A functional and biochemical interaction of TIS21/BTG2/PC3 with Forkhead box M1 (FoxM1),
essential transcription factor for hepatocyte regeneration and a master regulator of mitotic
gene expression, was explored. Growth of hepatocellular carcinoma (HCC), developed by a
single injection of diethylnitrosamine (DEN), was the same in both the TIS21+/+ and
TIS21−/− mice until 6 months, whereas it was significantly higher in the TIS21−/− mice at 9
months. Expression of TIS21 was significantly lower in both human and murine HCCs than …
essential transcription factor for hepatocyte regeneration and a master regulator of mitotic
gene expression, was explored. Growth of hepatocellular carcinoma (HCC), developed by a
single injection of diethylnitrosamine (DEN), was the same in both the TIS21+/+ and
TIS21−/− mice until 6 months, whereas it was significantly higher in the TIS21−/− mice at 9
months. Expression of TIS21 was significantly lower in both human and murine HCCs than …