NO modulates the molecular basis of rat interscapular brown adipose tissue thermogenesis
V Petrović, B Buzadžić, A Korać, A Vasilijević… - … and Physiology Part C …, 2010 - Elsevier
Molecular mechanisms underlying interscapular brown adipose tissue (IBAT)
thermogenesis were elucidated. Namely, gene and/or protein expression of uncoupling
protein 1 (UCP1), peroxisome proliferator-activated receptor γ (PPARγ), PPARγ-coactivator-
1α (PGC-1α), vascular endothelial growth factor (VEGF) and proliferating cell nuclear
antigen (PCNA)–key molecules that regulate thermogenesis-related processes–
mitochondriogenesis, angiogenesis and IBAT hyperplasia, in rats subjected to cold (4±1° C) …
thermogenesis were elucidated. Namely, gene and/or protein expression of uncoupling
protein 1 (UCP1), peroxisome proliferator-activated receptor γ (PPARγ), PPARγ-coactivator-
1α (PGC-1α), vascular endothelial growth factor (VEGF) and proliferating cell nuclear
antigen (PCNA)–key molecules that regulate thermogenesis-related processes–
mitochondriogenesis, angiogenesis and IBAT hyperplasia, in rats subjected to cold (4±1° C) …