Diabetic cardiomyopathy: the search for a unifying hypothesis

IG Poornima, P Parikh, RP Shannon - Circulation research, 2006 - Am Heart Assoc
IG Poornima, P Parikh, RP Shannon
Circulation research, 2006Am Heart Assoc
Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart
disease, less is known as to whether diabetes causes an altered cardiac phenotype
independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction,
left ventricular hypertrophy, and alterations in the coronary microcirculation have all been
observed, although not consistently, in diabetic cardiomyopathy and are not fully explained
by the cellular effects of hyperglycemia alone. The recent recognition that diabetes involves …
Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in diabetic cardiomyopathy and are not fully explained by the cellular effects of hyperglycemia alone. The recent recognition that diabetes involves more than abnormal glucose homeostasis provides important new opportunities to examine and understand the impact of complex metabolic disturbances on cardiac structure and function.
Am Heart Assoc