Protective role of ecto-5′-nucleotidase (CD73) in renal ischemia

A Grenz, H Zhang, T Eckle, M Mittelbronn… - Journal of the …, 2007 - journals.lww.com
Acute renal failure from ischemia significantly contributes to cardiovascular morbidity and
mortality. Extracellular adenosine has been implicated as an anti-inflammatory metabolite
particularly during conditions of limited oxygen availability (eg, ischemia). Because ecto-5′-
nucleotidase (CD73) is rate limiting for extracellular adenosine generation, this study
examined the contribution of CD73-dependent adenosine production to ischemic
preconditioning (IP) of the kidneys. After the initial observation that murine CD73 transcript …