Interaction of porphyrins with human organic anion transporting polypeptide 1B1
SD Campbell, WF Lau, JJ Xu - Chemico-biological interactions, 2009 - Elsevier
The existence of a porphyrin uptake transporter in hepatocytes has been hypothesized in
recent years, but to date it has not been identified. While the linear tetrapyrrole bilirubin has
been shown to be a substrate for the organic anion transporting polypeptide 1B1
(OATP1B1), similar studies have not been conducted for the cyclic tetrapyrroles (porphyrins).
The aim of this study was to determine the structural features of linear and cyclic tetrapyroles
necessary for interaction with OATP1B1. The interaction was quantified using HEK cells …
recent years, but to date it has not been identified. While the linear tetrapyrrole bilirubin has
been shown to be a substrate for the organic anion transporting polypeptide 1B1
(OATP1B1), similar studies have not been conducted for the cyclic tetrapyrroles (porphyrins).
The aim of this study was to determine the structural features of linear and cyclic tetrapyroles
necessary for interaction with OATP1B1. The interaction was quantified using HEK cells …