Elevated plasma homocysteine (Hcy) levels have been recognized as an independent risk
factor for atherosclerosis leading to cardiovascular diseases. However, the mechanisms
contributing to atherosclerosis have not been delineated. Since, scavenger receptors
mediated uptake of oxidized-LDL (oxLDL) by macrophages resulting in foam cell formation
is an early event in atherosclerosis, we hypothesized that atherogenic effects of Hcy may be
mediated via regulating expression of scavenger receptor (s). We have tested this …