[HTML][HTML] Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1
MZ Cui, MS Penn, GM Chisolm - Journal of Biological Chemistry, 1999 - ASBMB
Tissue factor, in association with factor VIIa, initiates the coagulation cascade. We studied
the influences of two pathophysiological stimuli, native (unmodified) and oxidized low
density lipoprotein, on tissue factor gene expression in a cell important in vascular
remodeling and vascular diseases, the smooth muscle cell. Our results demonstrated that
both lipoproteins significantly induced tissue factor gene expression in rat aortic smooth
muscle cells; oxidized low density lipoprotein was slightly more potent. Both lipoproteins …
the influences of two pathophysiological stimuli, native (unmodified) and oxidized low
density lipoprotein, on tissue factor gene expression in a cell important in vascular
remodeling and vascular diseases, the smooth muscle cell. Our results demonstrated that
both lipoproteins significantly induced tissue factor gene expression in rat aortic smooth
muscle cells; oxidized low density lipoprotein was slightly more potent. Both lipoproteins …