Enhanced procoagulatory activity (PCA) of human monocytes/macrophages after in vitro stimulation with chemically modified LDL
P Schuff-Werner, G Claus, VW Armstrong, H Kostering… - Atherosclerosis, 1989 - Elsevier
In cultured human monocytes/macrophages, surface expression of procoagulatory activity
(PCA) was induced by chemically modified LDL (acetyl-LDL and MDA-LDL) in a dose-and
time-dependent manner. Maximum PCA (30-fold increase) was detected after 24 h of culture
with modified LDL at doses of 25–750 μ protein/ml. Using factor VII deficient human plasma
and phospholipase C this PCA was identified as tissue thromboplastin activity (factor III).
These results suggest a further atherogenic potential for modified LDL through stimulation of …
(PCA) was induced by chemically modified LDL (acetyl-LDL and MDA-LDL) in a dose-and
time-dependent manner. Maximum PCA (30-fold increase) was detected after 24 h of culture
with modified LDL at doses of 25–750 μ protein/ml. Using factor VII deficient human plasma
and phospholipase C this PCA was identified as tissue thromboplastin activity (factor III).
These results suggest a further atherogenic potential for modified LDL through stimulation of …