Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice
N Hiraga, M Imamura, T Hatakeyama, S Kitamura… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: Both hepatitis B virus (HBV) and hepatitis C virus (HCV) replicate in
the liver and show resistance against innate immunity and interferon (IFN) treatment.
Whether there is interference between these two viruses is still controversial. We
investigated the interference between these two viruses and the mode of resistance against
IFN. METHODS: We performed infection experiments with either or both of the two hepatitis
viruses in human hepatocyte chimeric mice. Huh7 cell lines with stable production of HBV …
the liver and show resistance against innate immunity and interferon (IFN) treatment.
Whether there is interference between these two viruses is still controversial. We
investigated the interference between these two viruses and the mode of resistance against
IFN. METHODS: We performed infection experiments with either or both of the two hepatitis
viruses in human hepatocyte chimeric mice. Huh7 cell lines with stable production of HBV …