Endothelial heterogeneity in Shiga toxin receptors and responses
TG Obrig, CB Louise, CA Lingwood, B Boyd… - Journal of Biological …, 1993 - ASBMB
This study addresses the basis for regional microvascular susceptibility to bacterial toxins
implicated in hemolytic uremic syndrome. The results indicate a relationship between the
degree of Shiga toxin sensitivity of human endothelial cells from different sources and the
amount of globotriaosylceramide (Gb3) glycosphingolipid receptor for Shiga toxin expressed
by these cells. Cell viability and protein synthesis of renal endothelial cells were reduced to
50% by 1 pM Shiga toxin, while umbilical vein cells were not affected by> 1 nM toxin …
implicated in hemolytic uremic syndrome. The results indicate a relationship between the
degree of Shiga toxin sensitivity of human endothelial cells from different sources and the
amount of globotriaosylceramide (Gb3) glycosphingolipid receptor for Shiga toxin expressed
by these cells. Cell viability and protein synthesis of renal endothelial cells were reduced to
50% by 1 pM Shiga toxin, while umbilical vein cells were not affected by> 1 nM toxin …