The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
Y Takabatake, T Sugiyama, H Kohara… - Journal of the …, 2009 - journals.lww.com
Abstract CXC chemokine ligand 12 (CXCL12; stromal cell–derived factor 1) is a unique
homeostatic chemokine that signals through its cognate receptor, CXCR4. CXCL12/CXCR4
signaling is essential for the formation of blood vessels in the gastrointestinal tract during
development, but its contribution to renal development remains unclear. Here, we found that
CXCL12-secreting stromal cells surround CXCR4-positive epithelial components of early
nephrons and blood vessels in the embryonic kidney. In glomeruli, we observed CXCL12 …
homeostatic chemokine that signals through its cognate receptor, CXCR4. CXCL12/CXCR4
signaling is essential for the formation of blood vessels in the gastrointestinal tract during
development, but its contribution to renal development remains unclear. Here, we found that
CXCL12-secreting stromal cells surround CXCR4-positive epithelial components of early
nephrons and blood vessels in the embryonic kidney. In glomeruli, we observed CXCL12 …