Human embryonic stem cells reveal recurrent genomic instability at 20q11. 21
Nature biotechnology, 2008•nature.com
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we
identified a recurrent genomic instability in the human genome. An amplification of 2.5–4.6
Mb at 20q11. 21, encompassing∼ 23 genes in common, was detected in four cell lines of
different origins. This amplification, which has been associated with oncogenic
transformation, may provide a selective advantage to hES cells in culture.
identified a recurrent genomic instability in the human genome. An amplification of 2.5–4.6
Mb at 20q11. 21, encompassing∼ 23 genes in common, was detected in four cell lines of
different origins. This amplification, which has been associated with oncogenic
transformation, may provide a selective advantage to hES cells in culture.
Abstract
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing ∼23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.
nature.com