A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia
FM Mikhail, KA Serry, N Hatem, ZI Mourad… - Cancer genetics and …, 2002 - Elsevier
The AML1 gene (also known as RUNX1 or CBFA2), located in chromosome band 21q22,
encodes a transcription factor which heterodimerizes with the CBFβ protein forming a
complex called human core binding factor (CBF). The CBF complex appears to regulate a
number of genes important for hematopoiesis. AML1 is one of the most common targets of
chromosomal rearrangements in human leukemias and has been involved in 14
chromosomal translocations to date. Here we report a new chromosomal translocation, t (4; …
encodes a transcription factor which heterodimerizes with the CBFβ protein forming a
complex called human core binding factor (CBF). The CBF complex appears to regulate a
number of genes important for hematopoiesis. AML1 is one of the most common targets of
chromosomal rearrangements in human leukemias and has been involved in 14
chromosomal translocations to date. Here we report a new chromosomal translocation, t (4; …