[HTML][HTML] Determination of bone marrow–derived endothelial progenitor cell significance in angiogenic growth factor–induced neovascularization in vivo
T Murayama, OM Tepper, M Silver, H Ma… - Experimental …, 2002 - Elsevier
OBJECTIVE: Our laboratory and others recently provided evidence indicating that
endothelial progenitor cells (EPCs) participate in postnatal neovascularization. However, the
extent to which EPCs contribute to adult neovascularization remains unclear. To address
this issue, we investigated the quantitative contribution of EPCs to newly formed vascular
structures in an in vivo Matrigel plug assay and corneal micropocket assay. MATERIALS
AND METHODS: Lethally irradiated FVB mice were transplanted with bone marrow (BM) …
endothelial progenitor cells (EPCs) participate in postnatal neovascularization. However, the
extent to which EPCs contribute to adult neovascularization remains unclear. To address
this issue, we investigated the quantitative contribution of EPCs to newly formed vascular
structures in an in vivo Matrigel plug assay and corneal micropocket assay. MATERIALS
AND METHODS: Lethally irradiated FVB mice were transplanted with bone marrow (BM) …