[HTML][HTML] Refined characterization of corneodesmosin proteolysis during terminal differentiation of human epidermis and its relationship to desquamation
M Simon, N Jonca, M Guerrin, M Haftek… - Journal of Biological …, 2001 - ASBMB
Corneodesmosin is a putative adhesion glycoprotein located in the extracellular part of the
desmosomes in the upper layers of the epidermis. Synthesized by granular keratinocytes as
a 52–56-kDa protein, corneodesmosin is progressively proteolysed during corneocyte
maturation. This processing is a prerequisite for desquamation. Two glycine-and serine-rich
domains of the protein might take on the conformation of adhesive secondary structures
similar to glycine loops. Corneodesmosin proteolysis was further characterized …
desmosomes in the upper layers of the epidermis. Synthesized by granular keratinocytes as
a 52–56-kDa protein, corneodesmosin is progressively proteolysed during corneocyte
maturation. This processing is a prerequisite for desquamation. Two glycine-and serine-rich
domains of the protein might take on the conformation of adhesive secondary structures
similar to glycine loops. Corneodesmosin proteolysis was further characterized …