Skin undergoes self-renewal throughout life. Terminally differentiated keratinocytes, namely
the corneocytes, are continually shed from the surface of the skin, whereas immature cells
produce progeny that proceed through the differentiation process. Notch signaling controls a
number of cellular processes including cell fate decision, proliferation, differentiation and
survival/apoptosis. Hence, Notch and its ligands are expressed in multiple tissues including
the skin, where they are abundantly expressed in the epidermis. Notch activation results in …