[HTML][HTML] Protein kinase Cδ is activated by caspase-dependent proteolysis during ultraviolet radiation-induced apoptosis of human keratinocytes
MF Denning, Y Wang, BJ Nickoloff… - Journal of Biological …, 1998 - ASBMB
The elimination of ultraviolet (UV) radiation-damaged keratinocytes via apoptosis is an
important mechanism for the protection of the skin from sunlight, an ubiquitous
environmental carcinogen. Due to the pleiotropic nature of UV radiation, the molecular
mechanisms of UV-induced apoptosis are poorly understood. Protein kinase C (PKC) is a
family of enzymes critically involved in the regulation of differentiation in the epidermis, and
is associated with the induction of apoptosis by ionizing radiation in other cell types. In …
important mechanism for the protection of the skin from sunlight, an ubiquitous
environmental carcinogen. Due to the pleiotropic nature of UV radiation, the molecular
mechanisms of UV-induced apoptosis are poorly understood. Protein kinase C (PKC) is a
family of enzymes critically involved in the regulation of differentiation in the epidermis, and
is associated with the induction of apoptosis by ionizing radiation in other cell types. In …