The lymphatic system provides a route for dissemination of metastatic cancer cells. Yet to
date transient changes in lymphatic drainage pathways and function as a result of tumor
growth and metastasis have not been completely elucidated. Herein, we non-invasively
imaged functional and architectural lymphatic changes in mice with regional, palpable
lymph node (LN) involvement using dynamic near-infrared (NIR) fluorescence imaging with
intradermal injection of indocyanine green (ICG) to both tumor-free mice and mice bearing …