The presence of jaundice in the neonate, infant or young child presents a broad differential
diagnosis. The 'disease'may be benign, as in breast-milk jaundice, or potentially fatal, as in
hereditary fructose intolerance. The cause of the jaundice may be a primary hepatic
disorder, such as extrahepatic biliary atresia, or secondary to a non-hepatic cause, such as
haemolysis or sepsis. There may be significant hepatic injury and dysfunction, as in
fulminant viral hepatitis, or simply elevation of plasma bilirubin, as in Gilbert's syndrome. p] …