[HTML][HTML] Expression of the UDP-glucuronosyltransferase 1A locus in human colon: identification and characterization of the novel extrahepatic UGT1A8
CP Strassburg, MP Manns, RH Tukey - Journal of Biological Chemistry, 1998 - ASBMB
UDP-glucuronosyltransferases (UGT) catalyze the conjugation of lipophilic exobiotic and
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or
urine. By a mechanism of exon sharing, the transcripts of individual first exon cassettes
located at the 5′ end of the human UGT1Alocus are spliced to exons 2–5, leading to the
expression of at least nine individual UGT genes. Recently, the tissue-specific expression of
the UGT1A locus has been demonstrated in extrahepatic tissue, leading to the identification …
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or
urine. By a mechanism of exon sharing, the transcripts of individual first exon cassettes
located at the 5′ end of the human UGT1Alocus are spliced to exons 2–5, leading to the
expression of at least nine individual UGT genes. Recently, the tissue-specific expression of
the UGT1A locus has been demonstrated in extrahepatic tissue, leading to the identification …