Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded?: findings in 356 222 primary screenees of …

J Stamler, D Wentworth, JD Neaton - Jama, 1986 - jamanetwork.com
The 356 222 men aged 35 to 57 years, who were free of a history of hospitalization for
myocardial infarction, screened by the Multiple Risk Factor Intervention Trial (MRFIT) in its
recruitment effort, constitute the largest cohort with standardized serum cholesterol
measurements and long-term mortality follow-up. For each five-year age group, the
relationship between serum cholesterol and coronary heart disease (CHD) death rate was
continuous, gradecf, and strong. For the entire group aged 35 to 57 years at entry, the age …