[HTML][HTML] Defective hypothalamic autophagy directs the central pathogenesis of obesity via the IκB kinase β (IKKβ)/NF-κB pathway
Q Meng, D Cai - Journal of Biological Chemistry, 2011 - ASBMB
Autophagy has been recently demonstrated to control cell and tissue homeostasis, including
the functions of various metabolic tissues. However, it remains unclear whether autophagy is
critical for the central nervous system and particularly the hypothalamus for exerting
metabolic regulation. Using autophagy-related protein 7 (Atg7) as an autophagic marker,
this work showed that autophagy was highly active in the mediobasal hypothalamus of
normal mice. In contrast, chronic development of dietary obesity was associated with …
the functions of various metabolic tissues. However, it remains unclear whether autophagy is
critical for the central nervous system and particularly the hypothalamus for exerting
metabolic regulation. Using autophagy-related protein 7 (Atg7) as an autophagic marker,
this work showed that autophagy was highly active in the mediobasal hypothalamus of
normal mice. In contrast, chronic development of dietary obesity was associated with …