Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases
YL Chung, A Williams, D Ritchie, SCR Williams… - …, 1999 - journals.lww.com
Magnetic resonance imaging (MRI) has given inconsistent results when used as a non-
invasive diagnostic tool for Creutzfeldt–Jakob disease (CJD). In order to understand this
finding, we studied a hamster model of scrapie by in vivo MRI and histopathology.
Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and
hyper-intense changes in the conventional T2-weighted MR images, respectively. These
opposing effects were shown to give rise to normal images of a scrapie-affected brain …
invasive diagnostic tool for Creutzfeldt–Jakob disease (CJD). In order to understand this
finding, we studied a hamster model of scrapie by in vivo MRI and histopathology.
Vacuolation of neurones/neuropil and gliosis were found to correlate with hypo-intense and
hyper-intense changes in the conventional T2-weighted MR images, respectively. These
opposing effects were shown to give rise to normal images of a scrapie-affected brain …