[HTML][HTML] α4+ β7hiCD4+ memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection
M Kader, X Wang, M Piatak, J Lifson, M Roederer… - Mucosal …, 2009 - Elsevier
Human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infections are
believed to infect minimally activated CD4+ T cells after viral entry. Not much is known about
why SIV selectively targets these cells. Here we show that CD4+ T cells that express high
levels of the α4β7 heterodimer are preferentially infected very early during the course of SIV
infection. At days 2–4 post infection, α4+ β7 hi CD4+ T cells had∼ 5× more SIV-gag DNA
than β7− CD4+ T cells. α4+ β7 hi CD4+ T cells displayed a predominantly central memory …
believed to infect minimally activated CD4+ T cells after viral entry. Not much is known about
why SIV selectively targets these cells. Here we show that CD4+ T cells that express high
levels of the α4β7 heterodimer are preferentially infected very early during the course of SIV
infection. At days 2–4 post infection, α4+ β7 hi CD4+ T cells had∼ 5× more SIV-gag DNA
than β7− CD4+ T cells. α4+ β7 hi CD4+ T cells displayed a predominantly central memory …