Chk1 frameshift mutation in sporadic and hereditary non-polyposis colorectal cancers with microsatellite instability
CJ Kim, JH Lee, JW Song, YG Cho, SY Kim… - European Journal of …, 2007 - Elsevier
AIM: Protein kinase Chk1 (hChk1) is essential in human cells for cell cycle arrest in
response to DNA damage, and has been shown to play an important role in the G2/M
checkpoint. The BRAF mutations have been suggested to be linked with defective mismatch
repair in colorectal cancers. The aim of this study was to investigate whether a frameshift
mutation within the Chk1 gene contribute to the development or progression of eastern
sporadic and hereditary non-polyposis colorectal cancer (HNPCC) with microsatellite …
response to DNA damage, and has been shown to play an important role in the G2/M
checkpoint. The BRAF mutations have been suggested to be linked with defective mismatch
repair in colorectal cancers. The aim of this study was to investigate whether a frameshift
mutation within the Chk1 gene contribute to the development or progression of eastern
sporadic and hereditary non-polyposis colorectal cancer (HNPCC) with microsatellite …