Solitary cancer cells as a possible source of tumour dormancy?
GN Naumov, IC MacDonald, AF Chambers… - Seminars in cancer …, 2001 - Elsevier
GN Naumov, IC MacDonald, AF Chambers, AC Groom
Seminars in cancer biology, 2001•ElsevierMetastasis can occur many years after primary tumour treatment. However, the status of the
tumour during this period of dormancy is poorly understood. As part of our ongoing
experimental studies on mechanisms of metastasis, we have discovered that large numbers
of disseminated single cells may persist in secondary sites for extended time periods.
Identification of these cells was facilitated by in vivo techniques developed to quantify the
fate of individual cells during the metastatic process. Here we review these in vivo …
tumour during this period of dormancy is poorly understood. As part of our ongoing
experimental studies on mechanisms of metastasis, we have discovered that large numbers
of disseminated single cells may persist in secondary sites for extended time periods.
Identification of these cells was facilitated by in vivo techniques developed to quantify the
fate of individual cells during the metastatic process. Here we review these in vivo …
Metastasis can occur many years after primary tumour treatment. However, the status of the tumour during this period of dormancy is poorly understood. As part of our ongoing experimental studies on mechanisms of metastasis, we have discovered that large numbers of disseminated single cells may persist in secondary sites for extended time periods. Identification of these cells was facilitated by in vivo techniques developed to quantify the fate of individual cells during the metastatic process. Here we review these in vivo techniques and findings. We also discuss the potential clinical implications if dormant solitary cells exist in appreciable numbers in cancer patients.
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