Matrix metalloproteinase deficiencies do not impair cell-associated fibrinolytic activity
F Ugwu, G Lemmens, D Collen, HR Lijnen - Thrombosis research, 2001 - Elsevier
The matrix metalloproteinase (MMP) and fibrinolytic (plasminogen/plasmin) systems
cooperate in many (patho) physiological processes requiring extracellular proteolysis. The
effect of MMP-3 (stromelysin-1), MMP-7 (matrilysin), MMP-9 (gelatinase B) or MMP-12
(metalloelastase) on cellular fibrinolytic activity was studied with the use of smooth muscle
cells (SMC) and fibroblasts derived from mice with specific inactivation of these genes.
Activation of cell-bound plasminogen by two-chain urokinase-type plasminogen activator …
cooperate in many (patho) physiological processes requiring extracellular proteolysis. The
effect of MMP-3 (stromelysin-1), MMP-7 (matrilysin), MMP-9 (gelatinase B) or MMP-12
(metalloelastase) on cellular fibrinolytic activity was studied with the use of smooth muscle
cells (SMC) and fibroblasts derived from mice with specific inactivation of these genes.
Activation of cell-bound plasminogen by two-chain urokinase-type plasminogen activator …