[HTML][HTML] Nuclear retention of IκBα protects it from signal-induced degradation and inhibits nuclear factor κB transcriptional activation
MS Rodriguez, J Thompson, RT Hay… - Journal of Biological …, 1999 - ASBMB
Transcriptional activation of nuclear factor κB (NF-κB) is mediated by signal-induced
phosphorylation and degradation of its inhibitor, IκBα. However, NF-κB activation induces
rapid resynthesis of IκBα, which is responsible for post-induction repression of transcription.
Newly synthesized IκBα translocates to the nucleus, where it dissociates NF-κB from DNA
and transports NF-κB from the nucleus to the cytoplasm in a nuclear export sequence-
dependent process that is sensitive to leptomycin B (LMB). In the present study, LMB was …
phosphorylation and degradation of its inhibitor, IκBα. However, NF-κB activation induces
rapid resynthesis of IκBα, which is responsible for post-induction repression of transcription.
Newly synthesized IκBα translocates to the nucleus, where it dissociates NF-κB from DNA
and transports NF-κB from the nucleus to the cytoplasm in a nuclear export sequence-
dependent process that is sensitive to leptomycin B (LMB). In the present study, LMB was …