[HTML][HTML] Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system
DA Drechsel, M Patel - Journal of Biological Chemistry, 2010 - ASBMB
Mitochondrial reactive oxygen species (ROS) play an important role in both physiological
cell signaling processes and numerous pathological states, including neurodegenerative
disorders such as Parkinson disease. While mitochondria are considered the major cellular
source of ROS, their role in ROS removal remains largely unknown. Using polarographic
methods for real-time detection of steady-state H 2 O 2 levels, we were able to quantitatively
measure the contributions of potential systems toward H 2 O 2 removal by brain …
cell signaling processes and numerous pathological states, including neurodegenerative
disorders such as Parkinson disease. While mitochondria are considered the major cellular
source of ROS, their role in ROS removal remains largely unknown. Using polarographic
methods for real-time detection of steady-state H 2 O 2 levels, we were able to quantitatively
measure the contributions of potential systems toward H 2 O 2 removal by brain …