Insulin-like growth factor-I and bone: lessons from mice and men

M Kawai, CJ Rosen - Pediatric Nephrology, 2009 - Springer
M Kawai, CJ Rosen
Pediatric Nephrology, 2009Springer
Studies of humans and animals have illustrated a strong association between insulin-like
growth factor (IGF)-I and skeletal acquisition. However, the precise molecular and cellular
mechanisms underlying this effect still largely remain unknown. Recent advances in
molecular and genetic techniques for in vivo studies provide excellent tools for us to explore
how circulating and skeletal insulin-like growth factor-I (IGF-I) may affect not only peak bone
mass but also bone loss. This review highlights recent findings that shed new light on the …
Abstract
Studies of humans and animals have illustrated a strong association between insulin-like growth factor (IGF)-I and skeletal acquisition. However, the precise molecular and cellular mechanisms underlying this effect still largely remain unknown. Recent advances in molecular and genetic techniques for in vivo studies provide excellent tools for us to explore how circulating and skeletal insulin-like growth factor-I (IGF-I) may affect not only peak bone mass but also bone loss. This review highlights recent findings that shed new light on the interaction of the IGF-I signaling pathway with other skeletal networks, and the role of IGF-I in the bone marrow milieu.
Springer