Cxcl10 enhances blood cells migration in the sub-ventricular zone of mice affected by experimental autoimmune encephalomyelitis
L Muzio, F Cavasinni, C Marinaro… - Molecular and Cellular …, 2010 - Elsevier
The peri-ventricular area of the forebrain constitutes a preferential site of inflammation in
multiple sclerosis, and the sub-ventricular zone (SvZ) is functionally altered in its animal
model experimental autoimmune encephalomyelitis (EAE). The reasons for this preferential
localization are still poorly understood. We show here that, in EAE mice, blood-derived
macrophages, T and B cells and microglia (Mg) from the surrounding parenchyma
preferentially accumulate within the SvZ, deranging its cytoarchitecture. We found that the …
multiple sclerosis, and the sub-ventricular zone (SvZ) is functionally altered in its animal
model experimental autoimmune encephalomyelitis (EAE). The reasons for this preferential
localization are still poorly understood. We show here that, in EAE mice, blood-derived
macrophages, T and B cells and microglia (Mg) from the surrounding parenchyma
preferentially accumulate within the SvZ, deranging its cytoarchitecture. We found that the …