Voltage-clamp errors cause anomalous interaction between independent ion channels
In voltage-clamp, uncompensated series resistance results in steady-state voltage errors
that scale with the amplitude of the elicited current and are often correctable offline.
However, while investigating mechanoelectric transduction currents at hair cells' resting
potential, voltage-gated calcium channels and calcium-activated potassium channels (BK)
were activated in voltage-clamp by displacing the sensory hair bundle. This resulted from
steady-state voltage errors (< 1.5 mV) induced by series resistance changing the holding …
that scale with the amplitude of the elicited current and are often correctable offline.
However, while investigating mechanoelectric transduction currents at hair cells' resting
potential, voltage-gated calcium channels and calcium-activated potassium channels (BK)
were activated in voltage-clamp by displacing the sensory hair bundle. This resulted from
steady-state voltage errors (< 1.5 mV) induced by series resistance changing the holding …