[HTML][HTML] CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor (s)
K Nagata, H Hirai, K Tanaka, K Ogawa, T Aso… - FEBS letters, 1999 - Elsevier
K Nagata, H Hirai, K Tanaka, K Ogawa, T Aso, K Sugamura, M Nakamura, S Takano
FEBS letters, 1999•ElsevierWe have recently cloned a putative chemoattractant receptor, named CRTH2, which is
preferentially expressed on human T-helper-(Th) 2 but not Th1 cells. In this study, we
demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and
eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers
of a ligand. When stimulated with an anti-FcϵR1 antibody, cord blood-derived mast cells
secreted factor (s) that induced Ca2+ mobilization in CRTH2-expressing K562 cells but not …
preferentially expressed on human T-helper-(Th) 2 but not Th1 cells. In this study, we
demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and
eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers
of a ligand. When stimulated with an anti-FcϵR1 antibody, cord blood-derived mast cells
secreted factor (s) that induced Ca2+ mobilization in CRTH2-expressing K562 cells but not …
We have recently cloned a putative chemoattractant receptor, named CRTH2, which is preferentially expressed on human T-helper- (Th) 2 but not Th1 cells. In this study, we demonstrated that CRTH2 is also highly expressed on peripheral blood basophils and eosinophils. Our search for a CRTH2 ligand identified mast cells as the possible producers of a ligand. When stimulated with an anti-FcϵR1 antibody, cord blood-derived mast cells secreted factor(s) that induced Ca2+ mobilization in CRTH2-expressing K562 cells but not in mock transfected cells. These findings implied the involvement of CRTH2 in mast cell-mediated immune responses such as allergic reactions.
Elsevier