Clinical and basic science research carried out in recent years into herpes simplex
encephalitis (HSE) have shown that the concept of a “classical” picture of HSE in children is
now outdated and that our current knowledge of the disease is probably only the tip of an
iceberg. Indeed, increasing evidence supports the existence of a wider range of
pathophysiological mechanisms, clinical presentations and disease progressions in
paediatric HSE. This paper reviews the clinical, biological and radiological data available …