Long-term cognitive sequelae of acyclovir-treated herpes simplex encephalitis
B Gordon, OA Selnes, J Hart, DF Hanley… - Archives of …, 1990 - jamanetwork.com
• Survival from untreated herpes simplex type 1 encephalitis is well known to be
accompanied by severe cognitive impairments. Recently, acyclovir has been proven to be
the most effective available treatment for this disease, with the expectation that it would
appreciably reduce morbidity. We performed detailed assessments of four consecutive
patients who received acyclovir in the early stages of biopsy-proven herpes encephalitis and
who now have been followed up for 1.5 to 4 years. All four patients showed definite residual …
accompanied by severe cognitive impairments. Recently, acyclovir has been proven to be
the most effective available treatment for this disease, with the expectation that it would
appreciably reduce morbidity. We performed detailed assessments of four consecutive
patients who received acyclovir in the early stages of biopsy-proven herpes encephalitis and
who now have been followed up for 1.5 to 4 years. All four patients showed definite residual …