[HTML][HTML] The development of a metabolic disease phenotype in CTP: phosphoethanolamine cytidylyltransferase-deficient mice
MD Fullerton, F Hakimuddin, A Bonen… - Journal of Biological …, 2009 - ASBMB
Phosphatidylethanolamine (PE) is an important inner membrane phospholipid mostly
synthesized de novo via the PE-Kennedy pathway and by the decarboxylation of
phosphatidylserine. CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) catalyzes the
formation of CDP-ethanolamine, which is often the rate regulatory step in the PE-Kennedy
pathway. In the current investigation, we show that the reduced CDP-ethanolamine
formation in Pcyt2+/− mice limits the rate of PE synthesis and increases the availability of …
synthesized de novo via the PE-Kennedy pathway and by the decarboxylation of
phosphatidylserine. CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) catalyzes the
formation of CDP-ethanolamine, which is often the rate regulatory step in the PE-Kennedy
pathway. In the current investigation, we show that the reduced CDP-ethanolamine
formation in Pcyt2+/− mice limits the rate of PE synthesis and increases the availability of …