[HTML][HTML] Novel class of glycosphingolipids involved in male fertility
R Sandhoff, R Geyer, R Jennemann, C Paret… - Journal of Biological …, 2005 - ASBMB
Mice require testicular glycosphingolipids (GSLs) for proper spermatogenesis. Mutant mice
strains deficient in specific genes encoding biosynthetic enzymes of the GSL pathway
including Galgt1 (encoding GM2 synthase) and Siat9 (encoding GM3 synthase) have been
established lacking various overlapping subsets of GSLs. Although male Galgt1-/-mice are
infertile, male Siat9-/-mice are fertile. Interestingly, GSLs thought to be essential for male
spermatogenesis are not synthesized in either of these mice strains. Hence, these GSLs …
strains deficient in specific genes encoding biosynthetic enzymes of the GSL pathway
including Galgt1 (encoding GM2 synthase) and Siat9 (encoding GM3 synthase) have been
established lacking various overlapping subsets of GSLs. Although male Galgt1-/-mice are
infertile, male Siat9-/-mice are fertile. Interestingly, GSLs thought to be essential for male
spermatogenesis are not synthesized in either of these mice strains. Hence, these GSLs …