[HTML][HTML] The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-β repression of the sodium …
E Costamagna, B García, P Santisteban - Journal of Biological Chemistry, 2004 - ASBMB
Transforming growth factor-β (TGF-β) is a secreted protein that regulates proliferation,
differentiation, and death in various cell types, including thyroid cells, although few details
are known about its mechanisms of action in this cell type. Here, we studied the role of TGF-
β on the regulation of sodium/iodide symporter (NIS) gene expression in PC Cl3 thyroid
cells. TGF-β inhibits thyroid-stimulated hormone (TSH)-induced NIS mRNA and protein
levels in a dose-dependent manner. This effect takes place at the transcriptional level, as …
differentiation, and death in various cell types, including thyroid cells, although few details
are known about its mechanisms of action in this cell type. Here, we studied the role of TGF-
β on the regulation of sodium/iodide symporter (NIS) gene expression in PC Cl3 thyroid
cells. TGF-β inhibits thyroid-stimulated hormone (TSH)-induced NIS mRNA and protein
levels in a dose-dependent manner. This effect takes place at the transcriptional level, as …