Background Synapse loss has been found to be the major correlate of cognitive decline in
Alzheimer disease (AD), and prefrontal synapse loss has been found in patients with
frontotemporal dementia (FTD). Objective To see if our hypothesis that within each FTD
case, regional synapse loss would correlate with lateralizing neuropsychologic and
neurobehavioral deficits would be correct. Design We analyzed synaptophysin as a marker
for synapse loss in snap-frozen brain samples, using an enzyme-linked immunosorbent …