Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of lymphomas that present
clinically in the skin and are believed to be neoplastic proliferations of T cells that comprise
the skin-associated lymphoid tissue (SALT). The T-cells acquire adhesion molecules, such
as the cutaneous lymphocyte-associated antigen, as a consequence of exposures of naıve
cells to antigens in the skin and lymph nodes draining the skin. This programs the resultant
''memory''cells to circulate preferentially through the skin, regional nodes and back to the …