[PDF][PDF] Skp2, the FoxO1 hunter
E Dehan, M Pagano - Cancer cell, 2005 - cell.com
E Dehan, M Pagano
Cancer cell, 2005•cell.comSkp2 is an oncoprotein that mediates the degradation of several negative regulators of the
cell cycle to promote cell proliferation. A recent report by Huang and colleagues reveals that
Skp2 directs the ubiquitylation and subsequent degradation of FoxO1, a member of the
FoxO family of transcription factors. Since FoxO proteins possess tumor suppressor
functions, this new finding suggests a new mechanism by which Skp2 may favor
tumorigenesis.
cell cycle to promote cell proliferation. A recent report by Huang and colleagues reveals that
Skp2 directs the ubiquitylation and subsequent degradation of FoxO1, a member of the
FoxO family of transcription factors. Since FoxO proteins possess tumor suppressor
functions, this new finding suggests a new mechanism by which Skp2 may favor
tumorigenesis.
Skp2 is an oncoprotein that mediates the degradation of several negative regulators of the cell cycle to promote cell proliferation. A recent report by Huang and colleagues reveals that Skp2 directs the ubiquitylation and subsequent degradation of FoxO1, a member of the FoxO family of transcription factors. Since FoxO proteins possess tumor suppressor functions, this new finding suggests a new mechanism by which Skp2 may favor tumorigenesis.
cell.com