Pancreatic development and disease

DA Cano, M Hebrok, M Zenker - Gastroenterology, 2007 - gastrojournal.org
The last decade has seen tremendous advances in understanding the molecular
mechanisms that control vertebrate organogenesis. Transgenic animal models, mainly in
mouse and zebrafish, have allowed the mapping of endodermal cell specification toward
pancreas fate and the subsequent differentiation into distinct endocrine and exocrine cell
types. Using these sophisticated approaches, cell-type–specific activation or deactivation of
genes has become a reality. In some cases, these manipulations have provided crucial …