Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream
S Kennedy, S Rettinger, MW Flye, KP Ponder - Hepatology, 1995 - Elsevier
One hypothesis is that postnatal liver growth involves replication of mature hepatocytes,
which have an unlimited proliferative potential. An alternative viewpoint is that only certain
periportal cells can replicate extensively and that daughter cells stream slowly from the
periportal to the pericentral region of the liver. Transgenic mice expressing the beta-
galactosidase (β-gal) gene from the human al antitrypsin promoter were used to examine
the proliferative potential of hepatocytes. Surprisingly, only 10% of hepatocytes in two …
which have an unlimited proliferative potential. An alternative viewpoint is that only certain
periportal cells can replicate extensively and that daughter cells stream slowly from the
periportal to the pericentral region of the liver. Transgenic mice expressing the beta-
galactosidase (β-gal) gene from the human al antitrypsin promoter were used to examine
the proliferative potential of hepatocytes. Surprisingly, only 10% of hepatocytes in two …
