Resolution of serum and cerebrospinal fluid abnormalities after treatment of neurosyphilis: influence of concomitant human immunodeficiency virus infection
CM Marra, WT Longstreth Jr, CL Maxwell… - Sexually transmitted …, 1996 - journals.lww.com
CM Marra, WT Longstreth Jr, CL Maxwell, SA Lukehart
Sexually transmitted diseases, 1996•journals.lww.comStudy Design: Case series of 22 patients with neurosyphilis (13 infected with HIV) with
reactive cerebrospinal fluid Venereal Disease Research Laboratory test who underwent at
least one lumbar puncture after treatment. Results: Resolution of all serum and
cerebrospinal fluid measures was slower in patients infected with HIV. Serum and
cerebrospinal fluid abnormalities resolved in most patients not infected with HIV by 30
weeks, and all met Centers for Disease Control and Prevention criteria for cure. One patient …
reactive cerebrospinal fluid Venereal Disease Research Laboratory test who underwent at
least one lumbar puncture after treatment. Results: Resolution of all serum and
cerebrospinal fluid measures was slower in patients infected with HIV. Serum and
cerebrospinal fluid abnormalities resolved in most patients not infected with HIV by 30
weeks, and all met Centers for Disease Control and Prevention criteria for cure. One patient …
Study Design: Case series of 22 patients with neurosyphilis (13 infected with HIV) with reactive cerebrospinal fluid Venereal Disease Research Laboratory test who underwent at least one lumbar puncture after treatment.
Results: Resolution of all serum and cerebrospinal fluid measures was slower in patients infected with HIV. Serum and cerebrospinal fluid abnormalities resolved in most patients not infected with HIV by 30 weeks, and all met Centers for Disease Control and Prevention criteria for cure. One patient infected with HIV failed therapy by Centers for Disease Control and Prevention criteria, and three others had persistent pleocytosis.
Conclusions: HIV-infected patients with neurosyphilis have slower resolution of serum and cerebrospinal fluid abnormalities after therapy. This observation may suggest impaired clearance of Treponema pallidum from the central nervous system.
Lippincott Williams & Wilkins